iONE-FP7 published article in Organic Electronics journal

Organic field-effect transistor for label-free dopamine sensing

Organic Electronics 14 (2013) 156–163

Authors: Stefano Casalini, Francesca Leonardi, Tobias Cramer, Fabio Biscarini

Abstract: We describe a potentiometric sensor based on Electrolyte-Gated Organic Field-Effect Transistor (EGOFET) for ‘‘in vitro’’ detection of dopamine. The sensing element of this device resides at the Au gate–aqueous solution interface by means of a self-assembled monolayer (SAM) composed by cysteamine and 4-formylphenyl boronic acid. The covalent and selective adsorption of dopamine induces a surface dipole potential which shifts the electrode work function and modulates the double layer capacitance. As a result, our device is capable to detect dopamine up to pico-molar concentration showing higher sensitivity with respect to other approaches. For this reason the interface engineering of our EGOFET gate is a promising route for diagnostic applications.